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Scientific Literature
Authors:Birrell SN, Butler LM, Harris JM, Buchanan G, Tilley WD
Title:Disruption of androgen receptor signaling by synthetic progestins may increase risk of developing breast cancer.
Citation:FASEB J 2007 Apr 5; Epub ahead of print
Pub. Date:4/5/2007
Authors:Ribot C, Tremollieres F
Title:[Hormone replacement therapy in postmenopausal women: all the treatments are not the same.] TRANSLATION ATTACHED
Citation:Gynecol Obstet Fertil 2007 Mar 26; [Epub ahead of print]
Pub. Date:3/26/2007
Authors:Xu et al.
Title:Differential effects of progestogens, by type and regimen, on estrogen-metabolizing enzymes in human breast cancer cells.
Citation:Maturitas 2006 Sept 6 [Epub ahead of print]
Pub. Date:9/6/2006
Authors:Hyder SM
Title:Sex-steroid regulation of vascular endothelial growth factor in breast cancer.
Citation:Endocr Relat Cancer. 2006 Sep;13(3):667-87.
Pub. Date:9/1/2006
Authors:Wood CE, Register TC, Lees CJ, Chen H, Kimrey S, Mark Cline J
Title:Effects of estradiol with micronized progesterone or medroxyprogesterone acetate on risk markers for breast cancer in postmenopausal monkeys.
Citation:Breast Cancer Res Treat 2006 Jul 14; [Epub ahead of print]
Pub. Date:7/14/2006
Authors:Moskowitz D
Title:A Comprehensive Review of the Safety and Efficacy of Bioidentical Hormones for the Management of Menopause and Related Health Risks.
Citation:Alternative Medicine Review 2006;11(3):208-223
Pub. Date:1/1/2006
Authors:Cirpan, Terek, Ozsener, Kanit, Pogun, Zekioglu, Yucebilgin
Title:Proliferative effects of different hormone regimes on mammary glands in ovariectomized rats
Citation:Eur J Gynecol Oncol. 2006 27(3):256-261.
Pub. Date:1/1/2006
Authors:Campagnoli C, Abba C, Ambroggio S, Peris C.
Title:Pregnancy, progesterone and progestins in relation to breast cancer risk.
Citation:J Steroid Biochem Mol Biol. 2005 Oct 21; [Epub ahead of print]
Pub. Date:10/21/2005
Authors:Mirkin S, Wong BC, Archer DF.,
Title:Effect of 17beta-estradiol, progesterone, synthetic progestins, tibolone, and tibolone metabolites on vascular endothelial growth factor mRNA in breast cancer cells.
Citation:Fertil Steril. 2005 Aug;84(2):485-91.
Pub. Date:8/1/2005
Authors:Menendez JA, Oza BP, Colomer R, Lupu R.
Title:The estrogenic activity of synthetic progestins used in oral contraceptives enhances fatty acid synthase-dependent breast cancer cell proliferation and survival.
Citation:Int J Oncol. 2005 Jun;26(6):1507-15.
Pub. Date:6/1/2005
Authors:Proietti C, Salatino M, Rosemblit C, Carnevale R, Pecci A, Kornblihtt AR, Molinolo AA, Frahm I, Charreau EH, Schillaci R, Elizalde PV.
Title:Progestins induce transcriptional activation of signal transducer and activator of transcription 3 (Stat3) via a Jak- and Src-dependent mechanism in breast cancer cells.
Citation:Mol Cell Biol. 2005 Jun;25(12):4826-40.
Pub. Date:6/1/2005
Authors:Campagnoli C, Clavel-Chapelon F, Kaaks R, Peris C, Berrion F.
Title:Progestins and progesterone in hormone replacement therapy and the risk of breast cancer.
Citation:J Steroid Biochem Mol Biol. 2005 May 20; [Epub ahead of print]
Pub. Date:5/20/2005
Authors:Jordan VC.
Title:Medroxyprogesterone acetate and metastases: of mice and (wo)men.
Citation:J Natl Cancer Inst. 2005 May 4;97(9):619-21.
Pub. Date:5/4/2005
Authors:Fournier A, Berrino F, Riboli E, Avenel V, Clavel-Chapelon F., ,
Title:"Breast cancer risk in relation to different types of hormone replacement therapy in the E3N-EPIC cohort. "
Citation:Int J Cancer. 2005 Apr 10;114(3):448-54
Pub. Date:4/10/2005
Authors:Harman SM, Brinton EA, Cedars M, Lobo R, Manson JE, Merriam GR, Miller VM, Naftolin F, Santoro N.
Title:KEEPS: The Kronos Early Estrogen Prevention Study.
Citation:Climacteric. 2005 Mar;8(1):3-12.
Pub. Date:3/1/2005
Authors:Colditz GA,
Title:Estrogen, estrogen plus progestin therapy, and risk of breast cancer.
Citation:Clin Cancer Res. 2005 Jan 15;11(2 Pt 2):909s-17s
Pub. Date:1/15/2005
Authors:Missmer SA, Eliassen AH, Barbieri RL, Hankinson SE.
Title:Endogenous estrogen, androgen, and progesterone concentrations and breast cancer risk among postmenopausal women.
Citation:J Natl Cancer Inst. 2004 Dec 15;96(24):1856-65.
Pub. Date:12/15/2004
Authors:Moskowitz D.
Title:Comment on Bioidentical hormone therapy: a review". (and author reply)"
Citation:Menopause. 2004 Nov-Dec;11(6 Pt 1):639; author reply 639-41.
Pub. Date:11/1/2004
Authors:Druckmann, R
Title:Progestins and their effects on the breast.
Citation:Maturitas. 2003 Dec 10;46 Suppl 1:S59-69
Pub. Date:12/10/2003
Authors:Franke, HR, Vermes, I
Title:Differential effects of progestogens on breast cancer cell lines.
Citation:Maturitas. 2003 Dec 10;46 Suppl 1:S55-8
Pub. Date:12/10/2003
Authors:Mueck, AO, Seeger, H, Wallwiener, D
Title:Comparison of the proliferative effects of estradiol and conjugated equine estrogens on human breast cancer cells and impact of continuous combined progestogen addition.
Citation:Climacteric. 2003 Sep;6(3):221-7
Pub. Date:9/1/2003
Authors:Suparto IH, Williams JK, Cline JM, Anothony MS, Fox JL.
Title:Contrasting effects of two hormone replacement therapies on the cardiovascular and mammary gland outcomes in surgically postmenopausal monkeys.
Citation:Am J Obstet Gynecol. 2003 May;188(5):1132-40.
Pub. Date:5/1/2003
Authors:Seeger, H, Wallwiener, D, Mueck, AO
Title:The effect of progesterone and synthetic progestins on serum- and estradiol-stimulated proliferation of human breast cancer cells.
Citation:Horm Metab Res. 2003 Feb;35(2):76-80
Pub. Date:2/1/2003
Authors:Greendale, GA, Reboussin, BA, Slone, S, Wasilauskas, C, Pike, MC, Ursin, G
Title:Postmenopausal hormone therapy and change in mammographic density.
Citation:J Natl Cancer Inst. 2003 Jan 1;95(1):30-7
Pub. Date:1/1/2003
Authors:de Lignieres, B, Vathaire, F, Fournier, S, Urbinelli, R, Allaert, F, Le, M, Kuttenn, F
Title:Combined hormone replacement therapy and risk of breast cancer in a french cohort study of 3175 women.
Citation:Climacteric 2002;5:332-40
Pub. Date:1/1/2002
Authors:McCarty, MF
Title:Androgenic progestins amplify the breast cancer risk associated with hormone replacement therapy by boosting IGF-I activity.
Citation:Med Hypotheses. 2001 Feb;56(2):213-6
Pub. Date:2/1/2001
Authors:Greendale, GA, Reboussin, BA, Sie, A, Singh, HR, Olson, LK, Gatewood, O, Bassett, LW, Wasilauskas, C, Bush, T, Barrett-Connor, E
Title:Effects of estrogen and estrogen-progestin on mammographic parenchymal density. Postmenopausal Estrogen/Progestin Interventions (PEPI) Investigators.
Citation:Ann Intern Med. 1999 Feb 16;130(4 Pt 1):262-9
Pub. Date:2/16/1999
Authors:Foidart, JM, Colin, C, Denoo, X, Desreux, J, Beliard, A, Fournier, S, de Lignieres, B
Title:Estradiol and progesterone regulate the proliferation of human breast epithelial cells.
Citation:Fertil Steril. 1998 May;69(5):963-9
Pub. Date:5/1/1998
Authors:Espeland, M, Marcovina, S, Miller, V, Wood, P, Wasilauskas, C, Sherwin, R, Schrott, H, Bush, T
Title:Effect of postmeopausal hormone therapy on lipoprotein (a) concentration.
Citation:Circulation 1998;97:979-86
Pub. Date:3/14/1998
Authors:Staffa JA, Newschaffer CJ, Jones JK, Miller V.
Title:Progestins and breast cancer: an epidemiologic review
Citation:Fertil Steril. 1992 Mar;57(3):473-91. Review.
Pub. Date:3/1/1992
Authors:Birrell SN, Butler LM, Harris JM, Buchanan G, Tilley WD
Title:Disruption of androgen receptor signaling by synthetic progestins may increase risk of developing breast cancer.
Citation:FASEB J 2007 Apr 5; Epub ahead of print
Pub. Date:4/5/2007
Authors:Conner, P
Title:"Breast response to menopausal hormone therapy--aspects on proliferation, apoptosis and mammographic density. "
Citation:"Ann Med. 2007;39(1):28-41. Review. "
Pub. Date:4/1/2007
Authors:Ribot C, Tremollieres F
Title:[Hormone replacement therapy in postmenopausal women: all the treatments are not the same.] TRANSLATION ATTACHED
Citation:Gynecol Obstet Fertil 2007 Mar 26; [Epub ahead of print]
Pub. Date:3/26/2007
Authors:Fournier A, Berrino F, Clavel-Chapelon F.
Title:Unequal risks for breast cancer associated with different hormone replacement therapies: results from the E3N cohort study.
Citation:Breast Cancer Res Treat. 2007 Feb 27; [Epub ahead of print]
Pub. Date:2/27/2007
Authors:Canonico M, Oger E, Plu-Bureau G, Conard J, Meyer G, Levesque H, Trillot N, Barrellier MT, Wahl D, Emmerich J, Scarabin PY; Estrogen and Thromboembolism Risk (ESTHER) Study Group.
Title:Hormone therapy and venous thromboembolism among postmenopausal women: impact of the route of estrogen administration and progestogens: the ESTHER study.
Citation:Circulation. 2007 Feb 20;115(7):840-5.
Pub. Date:2/20/2007
Authors:Grady D, Vittinghoff E, Lin F, Hanes V, Ensrud K, Habel LA, Wallace R, Macer J, Cummings SR, Shepherd J.
Title:Effect of ultra-low-dose transdermal estradiol on breast density in postmenopausal women.
Citation:Menopause. 2007 Jan 11; [Epub ahead of print]
Pub. Date:1/11/2007
Authors:Moe RE, Anderson BO.
Title:"Androgens and androgen receptors: A clinically neglected sector in breast cancer biology. "
Citation:"J Surg Oncol. 2006 Dec 27; [Epub ahead of print] "
Pub. Date:12/27/2006
Authors:Ravdin PM, Cronin KA, Howlander N, Chlebowski RT, Berry DA
Title:A sharp decrease in breast cancer incidence in the United States in 2003.
Citation:San Antonio Breast Cancer Symposium Abstract #5, 12/14/2006 General Session
Pub. Date:12/14/2006
Authors:Lyytinen H, Pukkala E, Ylikorkala O
Title:Breast cancer risk in postmenopausal women using estrogen-only therapy.
Citation:Obstet Gynecol 2006 Dec;108(6):1354-60
Pub. Date:12/1/2006
Authors:Clarke CA, Glaser SL, Uratsu CS, Selby JV, Kushi LH, Herrinton LJ.
Title:Recent declines in HT utilization and breast cancer incidence.
Citation:J Clin Oncol. 2006 Nov 20;24(33):e49-50.
Pub. Date:11/20/2006
Authors:Hyder SM
Title:Sex-steroid regulation of vascular endothelial growth factor in breast cancer.
Citation:Endocr Relat Cancer. 2006 Sep;13(3):667-87.
Pub. Date:9/1/2006
Authors:Tamimi RM, Hankinson SE, Chen WY, Rosner B, Colditz GA
Title:Combined Estrogen and Testosterone Use and Risk of Breast Cancer in Postmenopausal Women
Citation:Arch Int Med 2006;166(14):1483-1489.
Pub. Date:7/24/2006
Authors:Wood CE, Register TC, Lees CJ, Chen H, Kimrey S, Mark Cline J
Title:Effects of estradiol with micronized progesterone or medroxyprogesterone acetate on risk markers for breast cancer in postmenopausal monkeys.
Citation:Breast Cancer Res Treat 2006 Jul 14; [Epub ahead of print]
Pub. Date:7/14/2006
Authors:Hsia J, Criqui MH, Herrington DM, Manson JE, Wu L, Heckbert SR, Allison M, McDermott MM, Robinson J, Masaki K
Title:Conjugated equine estrogens and peripheral arterial disease risk: the Women's Health Initiative.
Citation:Am Heart J 152(1):170
Pub. Date:7/1/2006
Authors:Benakanakere I, Besch-Willifors, SChnell J, Brandt S, Ellersieck MR, molinolo A, Hyder SM
Title:Natural and synthetic progestins accelerate 7,12-dimethylbenz[a]anthracene-initiated mammary tumors and increase angiogenesis in Sprague-Dawley rats.
Citation:Clin Cancer Res 2006 Jul1;12(13):4062-71
Pub. Date:7/1/2006
Authors:Zegura B et al.
Title:The effect of various menopausal hormone therapies on markers of inflammation, coagulation, fibrinolysis, lipids, and lipoproteins in healthy postmenopausal women.
Citation:Menopause 2006 Jul-Aug;13(4):643-50.
Pub. Date:7/1/2006
Authors:Anderson et al.
Title:Prior hormone therapy and breast cancer risk in the Women's Health Initiative randomized trial of estrogen plus progestin
Citation:Maturitas 2006
Pub. Date:7/1/2006
Authors:Li CI, Daling JR, Malone KE, Bernstein L, Marchbanks PA, Liff JM, Strom BL, Simon MS, Press MF, McDonald JA, Ursin G, Burkman RT, Deapen D, Spirtas R.
Title:Relationship between established breast cancer risk factors and risk of seven different histologic types of invasive breast cancer.
Citation:Cancer Epidemiol Biomarkers Prev. 2006 May;15(5):946-54.
Pub. Date:5/1/2006
Authors:Stefanick ML, Anderson GL, Margolis KL, Hendrix SL, Rodabough RJ, Paskett ED, Lane DS, Hubbell FA, Assaf AR, Sarto GE, Schenken RS, Yasmeen S, Lessin L, Chlebowski RT; WHI Investigators.
Title:Effects of conjugated equine estrogens on breast cancer and mammography screening in postmenopausal women with hysterectomy.
Citation:JAMA. 2006 Apr 12;295(14):1647-57.
Pub. Date:4/12/2006
Authors:Garcia-Perez MA, Moreno-Mercer J, Tarin JJ, Cano A
Title:Similar efficacy of low and standard doses of transdermal estradiol in controlling bone turnover in postmenopausal women.
Citation:Gynecol Endocrinol 2006 Apr;22(4):179-84.
Pub. Date:4/1/2006
Authors:Moskowitz D
Title:A Comprehensive Review of the Safety and Efficacy of Bioidentical Hormones for the Management of Menopause and Related Health Risks.
Citation:Alternative Medicine Review 2006;11(3):208-223
Pub. Date:1/1/2006
Authors:Kaaks et al.
Title:Postmenopausal serum androgens, oestrogens and breast cancer risk: the European prospective investigation into cancer and nutrition.
Citation:Endocr Relat Cancer 12(4):1071-82
Pub. Date:12/1/2005
Authors:Ghatge RP, Jacobsen BM, Schittone SA, Horwitz KB
Title:The progestational and androgenic properties of medroxyprogesterone acetate: gene regulatory overlap with dihydrotestosterone in breast cancer cells.
Citation:Breast Cancer Res2005;7(6):R1036-50. Epub 2005 Nov 2
Pub. Date:11/2/2005
Authors:Campagnoli C, Abba C, Ambroggio S, Peris C.
Title:Pregnancy, progesterone and progestins in relation to breast cancer risk.
Citation:J Steroid Biochem Mol Biol. 2005 Oct 21; [Epub ahead of print]
Pub. Date:10/21/2005
Authors:Mirkin S, Wong BC, Archer DF.,
Title:Effect of 17beta-estradiol, progesterone, synthetic progestins, tibolone, and tibolone metabolites on vascular endothelial growth factor mRNA in breast cancer cells.
Citation:Fertil Steril. 2005 Aug;84(2):485-91.
Pub. Date:8/1/2005
Authors:Ropponen A, Aittomaki K, Vihma V, Tikkanen MJ, Ylikorkala O.
Title:Effects of oral and transdermal estradiol administration on levels of sex hormone-binding globulin in postmenopausal women with and without a history of intrahepatic cholestasis of pregnancy.
Citation:J Clin Endocrinol Metab. 2005 Jun;90(6):3431-4. Epub 2005 Mar 22.
Pub. Date:6/1/2005
Authors:Campagnoli C, Clavel-Chapelon F, Kaaks R, Peris C, Berrion F.
Title:Progestins and progesterone in hormone replacement therapy and the risk of breast cancer.
Citation:J Steroid Biochem Mol Biol. 2005 May 20; [Epub ahead of print]
Pub. Date:5/20/2005
Authors:Fournier A, Berrino F, Riboli E, Avenel V, Clavel-Chapelon F., ,
Title:"Breast cancer risk in relation to different types of hormone replacement therapy in the E3N-EPIC cohort."
Citation:Int J Cancer. 2005 Apr 10;114(3):448-54
Pub. Date:4/10/2005
Authors:Matthews KA, Owens JF, Salomon K, Harris KF, Berga SL
Title:Influence of hormone therapy on the cardiovascular responses to stress of postmenopausal women.
Citation:Biol Psychol 2005 Apr;69(1):39-56. Epub 2005 Jan 4.
Pub. Date:4/1/2005
Authors:Dias AR, Melo RN, Gebara OC, D'Amico EA, Nussbacher A, Halbe HW, Pinotti JA
Title:Effects of conjugated equine estrogens or raloxifene on lipid profile, coagulation and fibrinolysis factors in postmenopausal women.
Citation:Climacteric 2005 Mar;8(1):63-70
Pub. Date:3/1/2005
Authors:Harman SM, Brinton EA, Cedars M, Lobo R, Manson JE, Merriam GR, Miller VM, Naftolin F, Santoro N.
Title:KEEPS: The Kronos Early Estrogen Prevention Study.
Citation:Climacteric. 2005 Mar;8(1):3-12.
Pub. Date:3/1/2005
Authors:Gambacciani M, Ciaponi M, Cappagli B, Monteleone P, Benussi C, Bevilacqua G, Vacca F, Genazzani AR.
Title:Effects of low-dose, continuous combined hormone replacement therapy on sleep in symptomatic postmenopausal women.
Citation:Maturitas. 2005 Feb 14;50(2):91-7.
Pub. Date:2/14/2005
Authors:Cirillo DJ, Wallace RB, Rodabough RJ, Greenland P, LaCroix AZ, Limacher MC, Larson JC,
Title:"Effect of estrogen therapy on gallbladder disease. "
Citation:JAMA. 2005 Jan 19;293(3):330-9
Pub. Date:1/19/2005
Authors:Ropponen A, Aittomaki K, Tikkanen MJ, Ylikorkala O
Title:Levels of serum C-reactive protein during oral and transdermal estradiol in postmenopausal women with and without a history of intrahepatic cholestasis of pregnancy.
Citation:J Clin Endocrinol Metab 2005 Jan;90(1):142-6. Epub 2004 Nov 2
Pub. Date:1/1/2005
Authors:Missmer SA, Eliassen AH, Barbieri RL, Hankinson SE.
Title:Endogenous estrogen, androgen, and progesterone concentrations and breast cancer risk among postmenopausal women.
Citation:J Natl Cancer Inst. 2004 Dec 15;96(24):1856-65.
Pub. Date:12/15/2004
Authors:Decensi A, Bonanni B, Baglietto L, et al.
Title:A two-by-two factorial trial comparing oral with transdermal estrogen therapy and fenretinide with placebo on breast cancer biomarkers.
Citation:Clin Cancer Res 2004 Jul 1;10(13):4389-97
Pub. Date:7/1/2004
Authors:Prifti S, Lelle I, Strowitzki T, Rabe T.
Title:Induction of androgen receptor activity by norgestimate and norelgestromin in MDA-MB 231 breast cancer cells.
Citation:Gynecol Endocrinol. 2004 Jul;19(1):18-21.
Pub. Date:7/1/2004
Authors:Hermsmeyer RK, Mishra RG, Pavcnik D, Uchida B, Axhelm MK, Stanczyk FZ, Burry KA, Illingworth DR, Juan C, Nordt FJ
Title:Prevention of coronary hyperreactivity in preatherogenic menopausal rhesus monkeys by transdermal progesterone.
Citation:Ateriosacler thromb Vasc Biol 2004 May;24(5):955-61.
Pub. Date:5/1/2004
Authors:Nelson, H
Title:Commonly used types of postmenopausal estrogen for treatment of hot flashes: scientific review.
Citation:JAMA 2004;291:1610-20
Pub. Date:4/7/2004
Authors:Minkin, MJ
Title:Considerations in the choice of oral vs. transdermal hormone therapy: a review.
Citation:J Reprod Med. 2004 Apr;49(4):311-20
Pub. Date:4/1/2004
Authors:Stahlberg, C, Pedersen, A, Lynge, E, Anderson, Z, Keiding, N, Hundrup, Y, Obel, E, Ottesen, B
Title:Increased risk of breast cancer following different regimens of hormone replacement therapy frequently used in Europe.
Citation:Int. J. Cancer:109,721-727 (2004)
Pub. Date:1/1/2004
Authors:Rosano G, Vitale C, Silvestri A, Fini M
Title:Metabolic and vascular effect of progestins in post-menopausal women ;Implications for cardioprotection
Citation:Maturitas 46 Suppl 1:17-29.
Pub. Date:12/10/2003
Authors:Schindler A, Campagnoli C, Drukmann R, Huber J, Pasqualini J, Schweppe KW, Thijssen JH
Title:Classification and pharmacology of progestins
Citation:Maturitas 46 Suppl 1:7-16
Pub. Date:12/10/2003
Authors:Schindler A
Title:Differential effects of progestins: European Progestin Club
Citation:Maturitas 2003;46 Suppl 1:s3-s5
Pub. Date:12/10/2003
Authors:Campagnoli, C, Abba, C, Ambroggio, S, Peris, C
Title:Differential effects of progestins on the circulating IGF-I system.
Citation:Maturitas. 2003 Dec 10;46 Suppl 1:S39-44
Pub. Date:12/10/2003
Authors:Nugent, AG, Leung, KC, Sullivan, D, Reutens, AT, Ho, KK
Title:Modulation by progestogens of the effects of oestrogen on hepatic endocrine function in postmenopausal women.
Citation:Clin Endocrinol (Oxf). 2003 Dec;59(6):690-8
Pub. Date:12/1/2003
Authors:Stanczyk, FZ
Title:All progestins are not created equal.
Citation:Steroids. 2003 Nov;68(10-13):879-90
Pub. Date:11/1/2003
Authors:Mueck, AO, Seeger, H, Wallwiener, D
Title:Comparison of the proliferative effects of estradiol and conjugated equine estrogens on human breast cancer cells and impact of continuous combined progestogen addition.
Citation: