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Estrogen and Natural Hormone Therapy
The following are facts, taught in medical school, facts even your doctor cannot disagree with.

They will educate you and empower you in any conversation with a health care provider, your friends or web search information you may read.

Estrogen is made in the ovaries, the follicle around the ovum, adrenal glands and fat cells. Estrogen is not one big molecule, it is a group of many molecules.

The three main molecules that make up estrogen are: estriol, estradiol, estrone. Estradiol (E2) es-TRA-di-ol–Estradiol is the most active form of estrogen made by our ovaries primarily when we are young, adrenals and fat cells as we get older.

Estradiol directly affects the functions of most of our body’s organs. Practically every cell in our body has on its surface receptors for estradiol. This means that estradiol can and will directly attach to every cell in our body. Once attached to the cell, estradiol enters the cell and influences its function.

Estradiol is the estrogen of youth. It is most abundant in young women in their teens and twenties. At this time in women’s lives, the incidence of cancer, stroke, heart disease and any other chronic diseases is minimal.

Estradiol is important in keeping women young. Women in this age group do not have wrinkles, or sagging skin.

They have plenty of estradiol. Estriol (E3) ES-tree-ol- Estriol is the weakest of estrogens. It is mainly made by the placenta. This means, estriol is most abundant during pregnancy.

Scientific research data on its function show limited positive effects; primarily to the vaginal walls and very little to the heart and bones. In non- pregnant women, estriol is made in the liver in small doses.

Its use in menopausal treatment is in the Biest and Triest formulations. Estrone (E1) es-TRONE- Estrone is made after menopause in fat cells primarily from testosterone derivatives (androstenedione- andro-STENE-di-own). Estrone has been implicated in the increased incidence of breast tumors found in aging women.

Most data have been obtained from animal studies. Overweight older women have high circulating levels of Estrone. A European study revealed higher levels of circulating Estrone in women with breast cancer.

It is used in Triest formulation by compounding pharmacies. Its use is unclear since it is already produced by menopausal women’s bodies and its effect is not positive.

When we refer to estrogen we refer to its three components as one. At times, this attempt to simplify creates errors in separating their individual function. Although their actions present as one in estrogen, the component molecules have different potencies.

During the aging process, the ovaries stop producing estrogen on a regular basis, and the main source of it in the body comes from the adrenal glands. The body transforms unused testosterone into needed estrogen and calls upon estrogen stored in fat cells as well.

Estrogen and progesterone are antagonists. Their actions are designed to balance each other, to keep each other in check. We cannot live in a healthy state without their balanced presence in our bodies.

As we begin to examine their individual effects keep in mind that at no time do they act independently, under normal circumstances in healthy bodies. Estrogen makes everything grow.

The positive effects of its action are that it:
  • Makes the lining of the uterus grow to prepare for pregnancy
  • Helps the breast tissues grow in preparation for making milk
  • Causes the ovum ( egg) to mature inside the ovary to prepare for ovulation
  • Creates the follicle where the egg matures
  • Promotes the growth of the fetus
  • Keeps the vagina, the vulva and the cervix well developed and moisturized
  • Promotes growth of underarm and pubic hair, and pigmentation of the nipples
  • Stimulates body fat accumulation to prevent starvation of the fetus
  • Prevents bone destruction by bone destroying cells (osteoclasts)
  • Protects from hypertension by relaxing the lining of blood vessels
  • Stimulates the production of lipoprotein lipase, an enzyme which breaks down fat. The result is low cholesterol levels and good balance between good (HDL) cholesterol and bad (LDL) cholesterol.
  • Lowers insulin levels
  • Induces relaxation of blood vessels in the circulation in general and heart in particular
The negative effects of the growth induced by estrogen unopposed (acting alone), without the balancing effects of progesterone are:
  • Increased accumulation of body fat
  • Increased water and salt retention
  • Interference with normal insulin release and blood sugar control
  • Increased risk of overgrowth of endometrium (lining of the uterus)
  • Increased risk of overgrowth of breast tissue
  • Increased risk of depression
  • Increased risk of headaches
  • Increased risk of gallbladder disease
  • Increased incidence of blood clot formation
Finally, when making decisions about the use of natural hormones- estradiol should be the estrogen of choice due to its abundance in young age and its lack of association with higher incidence of cancer, strokes and heart attacks.

But never use estradiol alone, remember to always use it in balance with progesterone.

Take my quick survey to see if your hormones are in balance
 
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